Design, Characterization and in vitro Simulations of nano-HAP/GO Composite Drug Delivery System Produced by Hydrothermal Methods Loaded with Paclitaxel
نویسندگان
چکیده
In this study, it was aimed to develop a nano drug system that can be used in passive targeting pancreatic cancer treatment. Hydroxyapatite nanocrystals (n-HAP) produced by hydrothermal process and graphene oxide (GO) hummers method were increase the carrier capacity of activate release kinetics loading capacity. Analyses performed for nanocomposite systems; FT-IR, XRD, TGA, BET analysis, Zeta potential, TEM SEM. Paclitaxel (PTX), chemotherapeutic treatment cancer, loaded into HAP (PTX- n-HAP) its activity on cells investigated. When PTX 1 2 mg, Encapsulation Efficiency (EE) Drug Loading Content (LC) 79.17-72.24% 80.01-80.27%, respectively, H-n-HAP crystal structure only, while EE LC 88.57-81.57% 90.84-110.57%, when with mg together GO. Here, observed profiles are according Hixson model. According Fick's law, profile values k=1.89, n=0.21, SSD=0.04, R2=0.997, FIC=2.03, SD=0.004. cell culture studies, as GO nanomaterials nanocrystal structure, effect increased viability decreased. It concluded H-n-HAP/GO/PTX kills more synergistic effect.
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ژورنال
عنوان ژورنال: Cumhuriyet Science Journal
سال: 2023
ISSN: ['2587-2680', '2587-246X']
DOI: https://doi.org/10.17776/csj.1258573